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来源:yl23455永利  发布时间:2017-03-20 访问次数:7872

    • 姓名:张学成











      张威 卢承会 赵荣娟李权 郑雪



      1.     内在无序蛋白的结构、聚集与功能机制

      2.     蛋白质的折叠机制

      3.     酶的结构与功能机制


      1.     MSP2的抗疟疾疫苗潜能相关性质的分子机制研究(国家自然科学基金面上项目)

      2.     细菌漆酶Lac15的半理性改造及其应用(安徽省对外科技合作计划项目)

      3.     疟原虫裂殖子表面蛋白MSP2 在类天然膜环境下的结构与聚集(安徽省高等学校省级自然科学研究重大项目)


      1.      Ye K, Tu X*, Zhang X*, Shang Q, Liao S,Yu J, Zhang J, Induced Folding Under Membrane Mimetic and Acidic ConditionsImplies Undiscovered Biological Roles of Prokaryotic Ubiquitin-Like Protein Pup.Protein Pept. Lett. (2016), 23, 756-762

      2.      Yang Y, Zhang X, Yin Q,Fang W, Fang Z, Wang X, Zhang X*, Xiao Y*. Amechanism of glucose tolerance and stimulation of GH1 β-glucosidases. Sci. Rep. (2015), 5:17296; doi:10.1038/srep17296

      3.      Fang Z, Zhou P, Chang F, Yin Q, Fang W, Yuan J, Zhang X*, Xiao Y*. Structure-based rational design toenhance the solubility and thermostability of a bacterial laccase Lac15. PLoS One (2014), 7, e102423

      4.     Fang Z, Li J, Wang Q, Fang W, Peng H, ZhangX*, XiaoY*.Anovel esterase from a marine metagenomic library exhibiting salt toleranceability. J. Microbiol. Biotechnol. (2014), 24,771-780

      5.     Zhang X*, Dong Y, Yu J, Tu X. Effectsof environmental factors on MSP21-25 aggregation indicate the rolesof hydrophobic and electrostatic interactions in the aggregation process. Eur.Biophys. J. (2014), 43, 1-9

      6.     Yu J, Wang C, Hu Y, Dong Y, Wang Y, Tu X, Peng H*, Zhang X*. Purification, crystallization and preliminarycrystallographic analysis of the marine α-amylase AmyP. Acta Cryst. (2013), F69, 263-266

      7.     Zhang X*, Adda CG, Low A, Zhang J, Zhang W, Sun H, Tu X, Anders RF, Norton RS. Role of the helicalstructure of the N-terminal region of Plasmodiumfalciparum merozoite surface protein 2 in fibril formation and membraneinteraction. Biochemistry (2012), 51, 1380-1387

      8.      Zhang X, Perugini M, Yao S, Adda CG, Murphy VJ, Low A,Anders RF., Norton RS. Solution conformation, backbone dynamics and lipidbinding of the intrinsically unstructured malaria surface protein MSP2. J. Mol.Biol. (2008), 379, 105-121

      9.      Zhang X, Xu Y, Zhang J, Wu J, Shi Y. Structural and dynamiccharacterization of the acid-unfolded state of hUBF HMG Box 1 provide clues forthe early events in protein folding. Biochemistry (2005), 44, 8117-8125

      10.  Zhang X, Zhang J, Li X, Xu J, Huang H, Chen Q, Wu J, Shi Y.Compact molten globule-like state of hUBF HMG Box1 at extremely low pH,Biochim. Biophys. Acta (2005), 1748, 66-73.